Carcinogenic metalloid arsenic induces expression of mdig oncogene through JNK and STAT3 activation
نویسندگان
چکیده
منابع مشابه
Interleukin-6 Induces S100A9 Expression in Colonic Epithelial Cells through STAT3 Activation in Experimental Ulcerative Colitis
BACKGROUND Intestinal epithelium is essential for maintaining normal intestinal homeostasis; its breakdown leads to chronic inflammatory pathologies, such as inflammatory bowel diseases (IBDs). Although high concentrations of S100A9 protein and interleukin-6 (IL-6) are found in patients with IBD, the expression mechanism of S100A9 in colonic epithelial cells (CECs) remains elusive. We investiga...
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Iron homeostasis is maintained through meticulous regulation of circulating hepcidin levels. Hepcidin levels that are inappropriately low or high result in iron overload or iron deficiency, respectively. Although hypoxia, erythroid demand, iron, and inflammation are all known to influence hepcidin expression, the mechanisms responsible are not well defined. In this report we show that the infla...
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Carcinogenic and systemic health effects of arsenic exposure in drinking water are well documented. This study estimated the risk associated with chronic consumption of water with high concentrations of arsenic in children and adults living in six Andean locations, in Chile. Concentrations of arsenic in the drinking water were analyzed between 2014 and 2017 based on health authority reports and...
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OBJECTIVES Glucocorticoids, such as dexamethasone (DEX), increase apoptosis in a variety of white cells in nasal polyps and apoptosis is an important factor in the resolution of inflammation. However, the mechanism of glucocorticoids induced apoptosis in nasal polyp remains unclear. In this study the authors evaluated which pathways were engaged in apoptosis induced by DEX in an ex vivo model o...
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STATs are latent transcription factors that mediate cytokine- and growth factor-directed transcription. In many human cancers and transformed cell lines, Stat3 is persistently activated, and in cell culture, active Stat3 is either required for transformation, enhances transformation, or blocks apoptosis. We report that substitution of two cysteine residues within the C-terminal loop of the SH2 ...
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ژورنال
عنوان ژورنال: Cancer Letters
سال: 2014
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2014.01.002